Dominga Rogolino


Curriculum Vitae

Dominga Rogolino obtained her degree in Chemistry cum laude at University of Parma in 1999 and the PhD in Chemistry in 2003 at the same University. Since 2002 she is Assistant Professor at the Department of Chemistry. The research activity is documented by 29 papers published in international journals, two book chapters (total number of publications: 31) and numerous presentations at national and international conferences. Dr. Rogolino is a member of the Italian Chemical Society and is a referee for scientific international journals. In 1999 (March-June) she spent a period in the laboratories of Prof. CJ Elsevier in the Department of Chemistry of the University of Amsterdam (The Netherlands). She collaborates with several Italian and foreign research groups:

  • Department of Chemistry and Pharmacy, University of Sassari (Dr. Mario Sechi )
  • Pharmaco- Chemical Department, University of Messina (Prof. Alba Chimirri )
  • Department of Chemistry, University of Florence (Dr. Claudiu Supuran )
  • College of Pharmacy, University of Michigan, USA (Prof. Nouri Neamati )
  • Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium (Prof. L. Naesens)

In 2011, dr. Rogolino was scientific tutor for the study “Esterification of glycerol and butyric acid: optimization of the Fisher reaction in order to maximize the yield of monobutyrin “for the optimization of the production process of monobutyrin to be used as animal feed for the company B.L.C. Technology Srl. She currently collaborates with the U.S. company Volare & Connecting LLC, with a study entitled “Development of innovative additives for animal nutrition”.


Main research themes

In recent years, the scientific interests have been directed to the synthesis and evaluation of biological activity of metal complexes as potential antiviral drugs. The ongoing research studies in fact indicate chelation as an effective strategy for the inhibition of metal-dependent enzymes (HIV integrase and RNase H, Influenza Virus Endonuclease). The study of these compounds is carried out both in solution and in the solid state by X-ray diffraction, NMR, IR, UV, CD spectroscopy and potentiometric measurements, in order to clarify which species are actually present at physiological pH. Another research theme is the synthesis of organometallic compounds that have been studied both in solution and in the solid state, highlighting in several cases good catalytic activity in various processes. In addition, she has collaborated to the study of organometallic systems that can bind to small neutral substrates at the solid state, as models for the processes of activation and control of the reactivity of substrates of biological and/or industrial interest.


6 most significant publications:

  1. Stevaert, R. Dallocchio, A. Dessi, N. Pala, D. Rogolino, M. Sechi, L. Naesens (2013). Mutational Analysis of the Binding Pockets of the Diketo Acid Inhibitor L-742,001 in the Influenza Virus PA Endonuclease. JOURNAL OF VIROLOGY, vol. 87, p. 10524-10538, ISSN: 0022-538X, doi: 10.1128/JVI.00832-13
  2. Rogolino, M. Carcelli, M. Sechi, N. Neamati (2012). Viral enzymes containing magnesium: metal binding as a successful strategy in drug design. COORDINATION CHEMISTRY REVIEWS, vol. 256, p. 3063-3086, ISSN: 0010-8545, doi: 10.1016/j.ccr.2012.07.006
  3. Bacchi, M. Carcelli, C. Compari, E. Fisicaro, N. Pala, G. Rispoli, D. Rogolino, T. Sanchez, N. Neamati, M. Sechi (2011). HIV-1 IN strand transfer inhibitors: a focus on metal binding. MOLECULAR PHARMACEUTICS, vol. 8(2), p. 507-519, ISSN: 1543-8384, doi: 10.1021/mp100343x
  4. Bacchi, M. Carcelli, C. Compari, E. Fisicaro, N. Pala, G. Rispoli, D. Rogolino, T.W. Sanchez, M. Sechi, V. Sinisi, N. Neamati (2011). Investigating the Role of Metal Chelation in HIV-1 Integrase Strand Transfer Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, p. 8407-8420, ISSN: 0022-2623, doi: 10.1021/jm200851g
  5. Sechi, A. Bacchi, M. Carcelli, C. Compari, M. Biemmi, E. Fisicaro, D. Rogolino, P. gates, M. Derudas, L. Q. AL-Mawsawi, N. Neamati (2008). From Ligand to Complexes. Part 2. Remarks on Human Immunodeficiency Virus Type 1 Integrase inhibition by β-Diketo Acid Metal Complexes. JOURNAL OF MEDICINAL CHEMISTRY, vol. 51 (22), p. 7253-7264, ISSN: 0022-2623, doi: 10.1021/jm800893q
  6. Sechi, A. Bacchi, M. Carcelli, C. Compari, E. Duce, E. Fisicaro, D. Rogolino, P. Gates, M. Derudas, L.Q. Al-Mawsawi, N. Neamati (2006). From Ligand to Complexes: Inhibition of HIV-1 Integrase by β-Diketo Acid Metal Complexes. JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, p. 4248-4260, ISSN: 0022-2623, doi: 10.1021/jm060193m

On-going research projects:

Progetto di ricerca RAS 2010: Progetti di ricerca fondamentale o di base, CRP-25920 Title:
“Sviluppo di nanodevices innovativi ad azione sito-specifica per la prevenzione, diagnosi e terapia del carcinoma prostatico” (6 person months)
PRIN 2010- Scientific coordinator Prof. M. Botta. Title: “Bloccare la replicazione di HIV-1 attraverso un approccio rivolto verso diversi bersagli molecolari” (9 person months)

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